Kitty in a hammock  TexAnne wrote 12 days ago

Hi. I'm new to this site & signed up because I take another blood thinner & wanted to understand about INR.

Category: INR

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Brachiosaurus  warrick - (1) - posted 12 days ago

Hi there, this wiki page is quite good to explain INR and PT- https://en.wikipedia.org/wiki/Prothrombin_time.
-a few excerts from previous posts of mine maybe of interest-
"INR is not a viable option when assessing the use of dabigatran or rivaroxaban. Additionally, PT is not a viable option when monitoring a patient on dabigatran. However, PT may be an option for monitoring select patients on rivaroxaban until more reliable standardized tests are developed. Methods of measuring the effectiveness of these agents are currently being developed and tested; however, until they are made available, the existing tests may be adapted to be used in a more effective manner."

"There are no blood tests required for plavix. It works later in the clotting mechanism and the inr would not reflect its effect.Hence it's not monitored,so one fixed dose for all it would seem. Plavix stops the platelets being able to stick or clump together to form a clot, where as warfarin works on the liver by blocking it from being able to use vit K to produce Fibrinogen, the "strings" in the blood that "grab" the platelets to form the clots"
"INR 1.0 normal person NOT on anticoagulants clotting time around 10 seconds INR 2.5-3.5 your range, so clotting time around 25-35 seconds Above that and the longer the clotting time goes until it starts to get risky (bleeding)which is generally considered INR 4.0-5.0 and above. Warfarin does not affect the viscosity of your blood, they just explain it that way because it's meant to be easier to understand, when they say it's thin thats a high INR and when it's considered too thick thats an INR lower than your target range ie INR 1.8 ."
Hope you find something useful in there, I'm not even sure what other anticoagulants can be monitored properly against the INR scale apart from warfarin which is due to the different ways the various drugs affect the clotting mechanism of the blood, warfarin I'm on for life with a mechanical valve from a birth defect.
What is your indication and what anticoagulant are you on ?

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Kitty in a hammock  TexAnne - - posted 11 days ago

Thanks for your reply. I take Eliquis for afib & my understanding is that there is no testing required for that drug. I'm wondering why not because I'm having bleeding problems associated with that. I'll probably have to change to another drug if we can't get that corrected.

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Brachiosaurus  warrick - (1) - posted 10 days ago

Sorry to hear of the bleeding issues.. not good at all. I'm not sure if there is any testing available for that drug or not sorry, that seems to me to be the issue with many of the other anticoagulants, the same general dose for everyone but everyone is different. If you do go onto warfarin I can only give my experience in that it has been very easy for me to manage and stay in range, I am 42, a heavy mechanic, and self test weekly with a coaguchek xs machine and purchase my own test strips out of pocket (about $7 New Zealand each), I record my dose weekly and I make any dose adjustments as needed myself. For me it keeps my INR in the safe range better than my doctor ever could.

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