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Sweet rabbits  nikhil wrote 5 months ago

Hi, I had my mitral valve surgery done in 2005. I has fitted with a metallic valve and have been on Warfarin since then.
Recently, I had been having a lot off issues with Warfarin and had a brain stroke followed by hemorrhagic transformation 5 months back. I did survive it, fortunately.

Now, with added medicines and a recent seiezure, my INR levels are flactuating a lot. My today report is 1.28 and I had been on 1mg/2mg alternate. I need to be between 2.0 and 3.0.
I just took a 3 mg to bump it up. How quickly does warfarin work?

Category: INR

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Brachiosaurus  warrick - (1) - posted 5 months ago

The range for a mechanical valve in the mitral position is 2.5-3.5, https://www.acc.org/latest-in-cardiology/articles/2015/05/18/09/58/anticoagulation-for-valvular-heart-disease
Warfarin affects everyone differently depending on metabolism but the half life is 20-60 hours depending on the person, I can see a change in my INR in 12 hours with dose changes. I self test with a coaguchek xs and manage my own dosing and have done for 4 1/2 years as I have a mechanical aortic valve. I have been 94% in range the last 12 months so self managment IMO is better than clinic and is easy to learn, after all its your life on the line so I prefer it to be in my own hands.
An INR of 1.28 or 1.4 is as you both must realise not good at all and needs to be dealt with promptly.
I suggest you check out this forum valvereplacement.org and start asking questions of fellow knowledgable valvers
https://www.valvereplacement.org/whats-new/

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Polar bear family  Gayle - - posted 5 months ago

I had the same thing, new valve in 2007, Stroke/cerebral hemorrhage in 2010. After my stroke my range went from 2.5-3.5 to 2.0-3.0. Unfortunately because I went to 1.4 about a month ago I got a small blood clot and had a minor heart attack. All the Dr.s freaked and my dose was majorly increased Im back to 2.5-3.5 with 2.5 being optimal any lower I can feel it. (I feel sick when it goes below 2, and to high I get a headache) The cardiologist I had for 34s years told me to never go below 2. I think it takes effect pretty quick I went from 1.4 to 3.8 in 1 week. I always go by how I feel I know when I need more or less. I told my new cardiologist Id rather bleed than have another heart attack.

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